Caffeine for the Treatment of Central Apnea in Trisomy 18: A Case Study in the Novel Use of Methylxanthines in Palliative Transport
| Autor: | Christopher A. Collura, Megan J. Thorvilson, Lezlie H. Andersen, Sydney Ariagno |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Apnea Central apnea Infant Premature Diseases chemistry.chemical_compound Caffeine Humans Medicine Intensive care medicine Apnea of prematurity Pathological General Nursing Cause of death business.industry Infant Newborn Infant General Medicine medicine.disease Sleep Apnea Central Anesthesiology and Pain Medicine chemistry Xanthines Central Nervous System Stimulants Female business Trisomy Infant Premature Trisomy 18 Syndrome |
| Zdroj: | Journal of Palliative Medicine. 25:840-843 |
| ISSN: | 1557-7740 1096-6218 |
| DOI: | 10.1089/jpm.2021.0383 |
| Popis: | Central apnea is a major cause of death in neonates with trisomy 18 (T18) and is likely due to immaturity of the respiratory drive, similar to the pathological mechanism in apnea of prematurity. Although caffeine has long been used for apnea of prematurity, its use has not yet been reported for infants with T18. Here we describe an infant with T18 receiving comfort-focused care and palliative transport home. Of utmost importance to her family was enabling the patient to spend time at home before her death. However, immediately before transport, she developed severe central apnea, raising concern that she may not survive the transfer. Caffeine was trialed in the hopes of reducing central apnea events. Its use was successful and facilitated safe transport, allowing the patient to uneventfully transition home, where she spent several meaningful weeks with her family before her death. |
| Databáze: | OpenAIRE |
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