Cell Delivery: Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag (Adv. Sci. 4/2020)

Autor:	Peter Horvath, Abel Szkalisity, Tamás A. Martinek, Ágnes Czibula, Brigitta Bodnár, Norbert Imre, Enikő Szabó, Éva Monostori, Ilona Gróf, Anasztázia Hetényi, Alexandra Bocsik, Mária A. Deli
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Glycan General Chemical Engineering General Physics and Astronomy Medicine (miscellaneous) 02 engineering and technology 010402 general chemistry Endocytosis 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) cell delivery endocytosis General Materials Science Inside Front Cover Lipid raft glycan Ganglioside biology Chemistry General Engineering 021001 nanoscience & nanotechnology Cell delivery 0104 chemical sciences Cell biology biology.protein peptides Antibody Routing (electronic design automation) 0210 nano-technology immunoglobulin
Zdroj:	Advanced Science
ISSN:	2198-3844
Popis:	In article number https://doi.org/10.1002/advs.201902621, Tamás A. Martinek and co‐workers develop a pentapeptidic tag, which reads the glycan code of ganglioside GM1 and triggers lipid raft‐mediated endocytosis, avoiding lysosomal entrapment. This carrier molecule can deliver macromolecular cargoes (e.g., IgG complexes) into live cells with the possibility to escape to the cytosol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2082eddfd9ca5c8f60f9fe77528c61d http://europepmc.org/articles/PMC7029659 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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