Effects of maternal medication use on NGF and IL-6 levels in human breast milk
| Autor: | Navya Talluri, Maya Maliekal, Rahul Rajkumar, Eunice Woldt, Holly Cox, Kashmira Wani, Marilynn R. Fairfax, Nitin Shasikant Chouthai |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Statistical significance Internal medicine Nerve Growth Factor Humans Medicine Interleukin 6 Human breast milk Analgesics Medication use Milk Human biology Interleukin-6 business.industry Obstetrics and Gynecology Anti-Bacterial Agents 030104 developmental biology Endocrinology Nerve growth factor Cytokine Pediatrics Perinatology and Child Health biology.protein business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 30:2287-2290 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2016.1247152 |
| Popis: | BACKGROUND The objective of this study was to evaluate the effect of maternal medications on nerve growth factor (NGF) and interleukin-6 (IL-6) levels in human breast milk (HBM). METHODS A total of 30 samples of HBM were collected after consent from consecutively born term newborns. NGF and IL-6 concentrations were analyzed using ELISA assays from R&D Systems. The HBM samples were centrifuged, and the clear portion of the HBM after discarding the fat was analyzed and cytokine data were expressed as NGFC or IL-6C. Ten samples of HBM, which were not centrifuged, were also used in ELISA assays and cytokine data were expressed as NGFF or IL-6F. RESULTS After exposure to NSAIDs (7636 ± 9610, mean ± SD, pg/mL), the NGFC levels in HBM were significantly higher as compared to those who were exposed to narcotics (522 ± 1000) (p = 0.008). NGFC and IL-6C levels positively correlated with each other in HBM (R = 0.194 p |
| Databáze: | OpenAIRE |
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