The design and implementation of the immune epitope database and analysis resource

Autor: Julia Ponomarenko, Ward Fleri, Grace Doh, Ralph T. Kubo, Alessandro Sette, Ole Lund, Phil Bourne, Buus Soeren, Scott Stewart, Mitch Kronenberg, Steve Wilson, John Sidney, Stephen P. Schoenberger, Muthu Sathiamurthy, Scott Way, Pamela Surko, Bjoern Peters, David Nemazee, Huynh-Hoa Bui
Rok vydání: 2005
Předmět:
Zdroj: Immunogenetics. 57:326-336
ISSN: 1432-1211
0093-7711
DOI: 10.1007/s00251-005-0803-5
Popis: Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, “The Immune Epitope Database and Analysis Resource.” We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.
Databáze: OpenAIRE
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