Formation of Well-Defined, Functional Nanotubes via Osmotically Induced Shape Transformation of Biodegradable Polymersomes
| Autor: | Jan C. M. van Hest, David S. Williams, Loai K. E. A. Abdelmohsen, Daniela A. Wilson, Sema G. Ozel, Jan Pille, Roger S. M. Rikken |
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| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular Soft Condensed Matter & Nanomaterials (HFML) Osmosis Nanostructure Membrane permeability Protein Conformation Polyesters Green Fluorescent Proteins Nanotechnology Context (language use) 02 engineering and technology Correlated Electron Systems / High Field Magnet Laboratory (HFML) 010402 general chemistry 01 natural sciences Biochemistry Bio-Organic Chemistry Catalysis Polyethylene Glycols chemistry.chemical_compound Colloid and Surface Chemistry Humans Well-defined GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Nanotubes Chemistry Communication General Chemistry Fibroblasts 021001 nanoscience & nanotechnology 0104 chemical sciences Polyester Polymersome Nanomedicine 0210 nano-technology Ethylene glycol |
| Zdroj: | Journal of the American Chemical Society Journal of the American Chemical Society, 138, 30, pp. 9353-9356 Journal of the American Chemical Society, 138, 9353-9356 |
| ISSN: | 0002-7863 |
| Popis: | Polymersomes are robust, versatile nanostructures that can be tailored by varying the chemical structure of copolymeric building blocks, giving control over their size, shape, surface chemistry, and membrane permeability. In particular, the generation of nonspherical nanostructures has attracted much attention recently, as it has been demonstrated that shape affects function in a biomedical context. Until now, nonspherical polymersomes have only been constructed from nondegradable building blocks, hampering a detailed investigation of shape effects in nanomedicine for this category of nanostructures. Herein, we demonstrate the spontaneous elongation of spherical polymersomes comprising the biodegradable copolymer poly(ethylene glycol)-b-poly(d,l-lactide) into well-defined nanotubes. The size of these tubes is osmotically controlled using dialysis, which makes them very easy to prepare. To confirm their utility for biomedical applications, we have demonstrated that, alongside drug loading, functional proteins can be tethered to the surface utilizing bio-orthogonal "click" chemistry. In this way the present findings establish a novel platform for the creation of biocompatible, high-aspect ratio nanoparticles for biomedical research. |
| Databáze: | OpenAIRE |
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