Additional file 1 of Berberine increases stromal production of Wnt molecules and activates Lgr5+ stem cells to promote epithelial restitution in experimental colitis

Autor: Luo, Zecheng, Li, Zihao, Liang, Zheng, Wang, Lin, He, Guanlin, Wang, Dongdi, Shen, Lei, Wang, Zhengting, Ma, Xiuying, Geng, Funeng, Wang, Haozhong, Liu, Wenping, Liu, Huijuan, Li, Baojie
Rok vydání: 2023
DOI: 10.6084/m9.figshare.22608661
Popis: Additional file 1: Table S1. Primer sequences used in the study. Fig. S1. Determining the optimal dose of BBR or SASP on colitis treatment. Fig. S2. Comparison of BBR and SASP on colitis after DSS withdrawal. Fig. S3. Gene expression profiling of rectal samples of BBR-treated normal mice. Fig. S4. BBR promotes the expression of mineral absorption genes. Fig. S5. Comparison of phenotypes at 03, 09, 15, and 21 of the day in DSS-induced colitis mice. Fig. S6. Gene expression profiling of samples of SASP-treated colitis mice. Fig. S7. Isotype controls for immune cell flow cytometry analysis. Fig. S8. Genotyping of the Lgr5-CreERT; Rosa-tdTomato mice. Fig. S9. The effect of BBR on β-Catenin and other signaling molecules in HCT116 cells. Fig. S10. Verification of the colonic stromal cells. Fig. S11. The effect of BBR on circadian gene expression in colorectal immune and epithelial cells.
Databáze: OpenAIRE