The Comparative Double-Blind Clinical Study in Antihelmintic Efficacy Between Thai Traditional Herbal Formulae and Mebendazole
| Autor: | Supachai Samappito, Gordon Bakker, Buavaroon Srichaikul, Surapote Wongyai |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Adolescent Mebendazole Helminthiasis Placebo law.invention Feces Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law parasitic diseases Humans Medicine Helminths Pharmacology (medical) 030212 general & internal medicine Intestinal Diseases Parasitic Eggs per gram Aged Anthelmintics Medicine East Asian Traditional Pharmacology 030219 obstetrics & reproductive medicine Traditional medicine business.industry General Medicine Middle Aged Thailand medicine.disease Inclusion and exclusion criteria Female business Phytotherapy medicine.drug |
| Zdroj: | American Journal of Therapeutics. 23:e1025-e1031 |
| ISSN: | 1075-2765 |
| DOI: | 10.1097/mjt.0b013e31824d6192 |
| Popis: | This study was carried out in Mahasarakham Primary Healthcare Centre, Mahasarakham province in the area of Northeastern of Thailand. The experiment was randomized controlled trial in the clinical study to examine the efficacy of Thai Traditional Herbal Formula (TTHF) in the treatment of antihelmintic activity of mixed worm infections in human. The 2 experimental groups consisted of 10 patients, and 5 patients for control group with inclusion and exclusion criteria, who were screened by the selection of mixed worm infection symptom samples. The investigation and extraction of worm eggs per gram (EPG) of patient feces method were performed with Ether-Formalin Sedimentation test. The percentage of reduction of EPG of patient feces were collected, counted, and confirmed by parasitologist, and the clinical efficacy was investigated by the physician and the pharmacist. The percent EPG data were collected before and after the treatment with TTHF and with mebendazole. The result showed that TTHF had higher efficacy in antihelmintic activity than mebendazole and placebo, which had the percent reduction of EPG of feces as 93.69 in TTHF and percent reduction of EPG of feces as 87.50 in mebendazole. The suggestion of this study should increase the number of samples of worm-infected patients, which the samples can be identified with the specific helminths genus and species to obtain the efficacy by the treatment using TTHF and mebendazole comparatively. |
| Databáze: | OpenAIRE |
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