The association between neonatal thyroxine and craniosynostosis, Texas, 2004-2007
| Autor: | S. Shahrukh Hashmi, Mark A. Canfield, Karen B. Moffitt, Susan Tanksley, Lisa Marengo, Debra Freedenberg, Philip J. Lupo, John W. Belmont |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Embryology Pediatrics medicine.medical_specialty Craniosynostosis Craniosynostoses Young Adult Neonatal Screening medicine Humans Gynecology Newborn screening Receiver operating characteristic business.industry Thyroid Infant Newborn Case-control study Area under the curve General Medicine medicine.disease Texas Thyroxine medicine.anatomical_structure ROC Curve Case-Control Studies Pediatrics Perinatology and Child Health Cranial sutures Female business Developmental Biology Isolated cases |
| Zdroj: | Birth Defects Research Part A: Clinical and Molecular Teratology. 94:1004-1009 |
| ISSN: | 1542-0752 |
| DOI: | 10.1002/bdra.23077 |
| Popis: | BACKGROUND Craniosynostosis (CS), a structural anomaly characterized by premature fusion of cranial sutures, occurs in 1 in 2000 live births. Associations of CS with the thyroid have been reported. Neonatal thyroid hormone (T4) is evaluated nationally at birth by the Newborn Screening Program (NBS). This study evaluated the relationship between NBS T4 levels and craniosynostosis. METHODS Live-born singleton babies born in 2004 through 2007 were identified through the Texas Birth Defects Registry (499 cases) and Texas Bureau of Vital Statistics (3570 controls) and successfully linked to analyte data available in the Texas NBS Database. Cases were classified based on the absence of other major defects (isolated cases, n = 382) and suture(s) involved. Mean T4 levels were compared between controls and cases (overall and stratified by classification). T4 levels were stratified by quintiles to evaluate differences between cases and controls within quintiles. The diagnostic utility of NBS T4 was evaluated using receiver operator characteristic (ROC) curves. RESULTS Mean T4 levels were lower in isolated cases (16.89 μg/dl) than in controls (17.77 μg/dl; p = 0.0004). This trend persisted for sagittal (16.69 μg/dl; p = 0.002) and metopic (16.83 μg/dl; p = 0.042) CS. When stratified by quintiles, 54% of isolated lambdoid CS were in the first quintile compared to controls (p = 0.012). ROC area under the curve (AUC) was approximately 0.55 for all classifications except lambdoid (AUC = 0.73). CONCLUSION NBS T4 levels were slightly lower among cases with nearly half of all lambdoid CS having T4 levels in the lowest quintile. However, overall NBS T4 levels are not suitable for potential screening or diagnostic application. Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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