Hematological differences between patients with different subtypes of sickle cell disease on hydroxyurea treatment
| Autor: | Larissa Bueno Polis, Ana Cristina Silva-Pinto, Sarah Cristina Bassi, Ivan L. Angulo, Denise Menezes Brunetta, Fábia Neves, Osvaldo Alves Menezes Neto |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pediatrics
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Mean corpuscular hemoglobin Gastroenterology Internal medicine hemic and lymphatic diseases medicine Hydroxyurea Mean corpuscular volume medicine.diagnostic_test business.industry lcsh:RC633-647.5 Microcytosis Complete blood count Beta thalassemia Erythrocyte indices Retrospective cohort study Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease Sickle cell anemia Anemia sickle cell Hemoglobinopathies Hypochromia Original Article business |
| Zdroj: | Revista Brasileira de Hematologia e Hemoterapia, Vol 34, Iss 6, Pp 426-429 (2012) Revista Brasileira de Hematologia e Hemoterapia v.34 n.6 2012 Revista brasileira de hematologia e hemoterapia Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC Revista Brasileira de Hematologia e Hemoterapia, Volume: 34, Issue: 6, Pages: 426-429, Published: 2012 Revista Brasileira de Hematologia e Hemoterapia |
| ISSN: | 1806-0870 1516-8484 |
| Popis: | OBJECTIVE: Sickle cell anemia and the interaction S/Beta thalassemia differ in hematological values due to microcytosis and hypochromia caused by the thalassemic mutation. The clinical benefit of long-term hydroxyurea treatment is undeniable in sickle cell disease with monitoring of the biological action of the drug being by the complete blood count. The objective of this work is to compare changes in some of the erythrocytic indexes between S/Beta thalassemia and sickle cell anemia patients on long-term hydroxyurea treatment. METHODS: The values of erythrocyte indexes (mean corpuscular volume and mean corpuscular hemoglobin) were compared in a retrospective study of two groups of patients (Sickle cell anemia and S/Beta thalassemia) on hydroxyurea treatment over a mean of six years. RESULTS: The quantitative values of the two parameters differed between the groups. Increases in mean corpuscular volume and reductions in mean corpuscular hemoglobin delay longer in S/Beta thalassemia patients (p-value = 0.018). CONCLUSION: Hematological changes are some of the beneficial effects of hydroxyurea in sickle cell disease as cellular hydration increases and the hemoglobin S concentration is reduced. The complete blood count is the best test to monitor changes, but the interpretation of the results in S/Beta thalassemia should be different. |
| Databáze: | OpenAIRE |
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