Impact of chemical peeling combined with negative pressure on human skin
| Autor: | In Jung Kang, Ki-Heon Jeong, Jae Sook Koh, Sang Jun Lee, Ji Hwoon Baek, So Jeong Kim, Min Kyung Shin |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Aging Skin barrier Pharmaceutical Science Human skin Dermatology 030226 pharmacology & pharmacy Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Colloid and Surface Chemistry Dermis In vivo Drug Discovery Humans Medicine Skin Skin damage Transepidermal water loss integumentary system business.industry Middle Aged Skin colour medicine.anatomical_structure Chemistry (miscellaneous) Anesthesia Chemical peeling Female business |
| Zdroj: | International Journal of Cosmetic Science. 38:440-443 |
| ISSN: | 0142-5463 |
| Popis: | OBJECTIVE In vivo changes in skin barrier function after chemical peeling with alpha hydroxyacids (AHAs) have been previously reported. However, the additional effects of physical treatment with chemical agents on skin barrier function have not been adequately studied. This study measured the degree of acute skin damage and the time required for skin barrier repair using non-invasive bioengineering methods in vivo with human skin to investigate the additional effect of a 4% AHA chemical jet accelerated at supersonic velocities. METHODS Thirteen female subjects (average age: 29.54 ± 4.86 years) participated in this study. The faces of the subjects were divided into half according to the block randomization design and were then assigned to receive AHA peeling alone or AHA peeling combined with pneumatic pressure on each side of the face. Transepidermal water loss (TEWL), skin colour and skin blood flow were evaluated at baseline and at 30 min, 2, 5 and 7 days after treatment. RESULTS The TEWL and skin blood flow were significantly increased after 30 min in chemodermabrasion compared with chemical peeling alone (P < 0.05). The TEWL and skin blood flow recovered to baseline after 2 days, and TEWL was significantly decreased at 7 days compared with chemical peeling alone (P < 0.05). CONCLUSIONS Chemodermabrasion can temporarily impair skin barriers, but it is estimated that it can enhance the skin barrier function after 7 days compared to the use of a chemical agent alone. In addition, chemodermabrasion has a more effective impact in the dermis and relatively preserves the skin barrier. |
| Databáze: | OpenAIRE |
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