Cerebellar hypoplasia and dysplasia in a juvenile raccoon with parvoviral infection
Autor: | Colin R. Parrish, Arno Wünschmann, Aníbal G. Armién, Robert Lopez-Astacio |
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Rok vydání: | 2020 |
Předmět: |
Cerebellum
Parvovirus Canine 040301 veterinary sciences Developmental Disabilities viruses Biology Nervous System Malformations Polymerase Chain Reaction Virus Parvoviridae Infections 0403 veterinary science 03 medical and health sciences medicine Animals 030304 developmental biology 0303 health sciences General Veterinary Parvovirus Canine parvovirus Rabies testing 04 agricultural and veterinary sciences medicine.disease biology.organism_classification Immunohistochemistry Virology Hypoplasia medicine.anatomical_structure Dysplasia Female Raccoons Cerebellar hypoplasia (non-human) Brief Communications |
Zdroj: | J Vet Diagn Invest |
ISSN: | 1943-4936 1040-6387 |
Popis: | A juvenile raccoon ( Procyon lotor) was submitted dead to the Minnesota Veterinary Diagnostic Laboratory for rabies testing without history. The animal had marked hypoplasia of the cerebellum. Histology demonstrated that most folia lacked granule cells and had randomly misplaced Purkinje cells. Immunohistochemistry revealed the presence of parvoviral antigen in a few neurons and cell processes. PCR targeting feline and canine parvovirus yielded a positive signal. Sequencing analyses from a fragment of the nonstructural protein 1 ( NS1) gene and a portion of the viral capsid protein 2 ( VP2) gene confirmed the presence of DNA of a recent canine parvovirus variant (CPV-2a–like virus) in the cerebellum. Our study provides evidence that (canine) parvovirus may be associated with cerebellar hypoplasia and dysplasia in raccoons, similar to the disease that occurs naturally and has been reproduced experimentally by feline parvoviral infection of pregnant cats, with subsequent intrauterine or neonatal infections of the offspring. |
Databáze: | OpenAIRE |
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