Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells
| Autor: | Keiji Tanaka, Shigeo Murata, Kenneth L. Rock, Eleanor Kincaid |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Proteasome Endopeptidase Complex Cellular differentiation T cell Immunology Antigen presentation Thymus Gland Biology CD8-Positive T-Lymphocytes Article 03 medical and health sciences Negative selection Mice mental disorders medicine Immunology and Allergy Cytotoxic T cell Humans Animals Clonal Selection Antigen-Mediated Selection (genetic algorithm) Cells Cultured Genetics Mice Knockout Antigen Presentation Histocompatibility Antigens Class I Cell Differentiation Mice Inbred C57BL Cysteine Endopeptidases 030104 developmental biology medicine.anatomical_structure Proteasome Female Peptides CD8 |
| Zdroj: | Nature immunology |
| ISSN: | 1529-2916 |
| Popis: | The cells that stimulate positive selection express specialized proteasome β-subunits different from those expressed by all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome β-subunits, and therefore express only constitutive proteasomes in all cells, had a profound defect in the generation of CD8(+) T cells. While a defect in positive selection would reflect an inability to generate the appropriate positively selecting peptides, a block at negative selection would point to the potential need to switch peptides between positive selection and negative selection to avoid the two processes' often cancelling each other out. We found that the block in T cell development occurred around the checkpoints of positive selection and, unexpectedly, negative selection as well. |
| Databáze: | OpenAIRE |
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