Association study of polymorphisms in the SOST gene region and parameters of bone strength and body composition in both young and elderly men : data from the Odense Androgen Study
| Autor: | Elke Piters, Marianne Andersen, Fenna de Freitas, Kim Brixen, Wim Van Hul, Torben Leo Nielsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Genetic Markers Male medicine.medical_specialty Genotype Bone density Denmark Endocrinology Diabetes and Metabolism Osteoporosis Single-nucleotide polymorphism Body Mass Index Cohort Studies chemistry.chemical_compound Endocrinology Bone Density Internal medicine medicine Humans Orthopedics and Sports Medicine Genetic Association Studies Adaptor Proteins Signal Transducing Aged Femoral neck Bone mineral Polymorphism Genetic Femur Neck business.industry Middle Aged medicine.disease Minor allele frequency Low Density Lipoprotein Receptor-Related Protein-5 medicine.anatomical_structure chemistry Bone Morphogenetic Proteins Body Composition Sclerostin Human medicine business Body mass index |
| Zdroj: | Calcified tissue international Piters, E, de Freitas, F, Nielsen, T L, Andersen, M, Brixen, K & Van Hul, W 2011, ' Association Study of Polymorphisms in the SOST Gene Region and Parameters of Bone Strength and Body Composition in Both Young and Elderly Men: Data from the Odense Androgen Study ', Calcified Tissue International, vol. 90, no. 1, pp. 30-39 . https://doi.org/10.1007/s00223-011-9546-5 |
| ISSN: | 0171-967X 1053-4024 |
| DOI: | 10.1007/s00223-011-9546-5 |
| Popis: | By means of different genetic association studies the SOST gene, encoding sclerostin, has repeatedly been suggested to regulate bone mineral density (BMD) and osteoporosis susceptibility. This study aimed at a further understanding of the importance of two previously studied single-nucleotide polymorphisms in the SOST gene, rs10534024 (SRP3) and rs9902563 (SRP9), in the Odense Androgen Study (OAS) cohort. This cohort includes a total of 1,383 Danish men from two different age groups, 20-29 years (n = 783) and 60-74 years (n = 600), and is well characterized. Subjects were phenotyped for BMD at several sites and additionally for body composition and hip geometric parameters. In a combined analysis of the young and the elderly OAS, no associations were found for SRP3 either with BMD or with hip geometry. Instead, we found that this polymorphism had a relatively large effect on weight (-1.149 kg) and body mass index (-0.389 kg/m(2)) (P = 0.021 and 0.006 under a codominant model). For SRP9, a significant association was found for femoral neck BMD (+0.020 g/cm(2), P = 0.020) and a trend toward significance for hip geometry (buckling ratio of the narrow neck) but only when considering a recessive effect of the minor allele (C). No age-specific effects were found for either of the two SNPs. In summary, we are the first to find interesting associations between SRP3 and body composition. For SRP9, we replicated a site-specific association with femoral neck BMD. In addition, we report a novel association for this polymorphism with hip geometry. |
| Databáze: | OpenAIRE |
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