Differential trajectories of neurocognitive functioning in females versus males following treatment for pediatric brain tumors
| Autor: | Sophia Shonka, David Breiger, Sarah Leary, J. Russell Geyer, Jesse Bledsoe, Ralph P. Ermoian, Micah Breiger, David M Werny, Jeffrey G. Ojemann |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research Pediatrics medicine.medical_specialty medicine.medical_treatment Intelligence Infratentorial Neoplasms Standard score medicine Humans Clinical significance Child Radiation Injuries Retrospective Studies Sex Characteristics Intelligence quotient business.industry Wechsler Scales Editorials Brain Chemotherapy regimen Sexual dimorphism Radiation therapy Oncology Female Neurology (clinical) Cranial Irradiation business Cognition Disorders Neurocognitive Sex characteristics |
| Zdroj: | Neuro Oncol |
| ISSN: | 1523-5866 |
| Popis: | BackgroundFemale and male trajectories of cerebellar and lobar brain structures are sexually dimorphic, making sex a potential candidate moderator of neurocognitive late effects from radiation treatment. We sought to evaluate longitudinal neurocognitive functioning in male versus female children treated for posterior fossa brain tumors.MethodsFifty-one female and 63 male survivors of posterior fossa tumors completed neuropsychological testing at 2 timepoints. We included patients treated with surgical resection, chemotherapy, and radiation therapy. Multilevel mixed modeling was used to predict IQ score as a function of patient sex following treatment (~2 or ~4 years post treatment). Effect sizes were used as a measure of clinical significance.ResultsMultilevel models resulted in a significant sex by time interaction (F = 6.69, P = 0.011). Females’ cognitive scores were considerably higher compared with males at 4 years posttreatment. Females demonstrated an average improvement of 7.61 standard score IQ points compared with a decline of 2.97 points for males at 4 years follow-up. Effect sizes for female IQ compared with male IQ at 4 years posttreatment were between 0.8 and 0.9.ConclusionTrajectories of neurocognitive functioning following posterior fossa tumor treatment differed between female and male children. Sexual dimorphism in radiation late effects may alter treatment decisions in children. Research into sex-specific neuroprotective mechanisms underlying neurocognitive development following pediatric brain tumor treatments is warranted. |
| Databáze: | OpenAIRE |
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