Association between GNB3 c.825C>T polymorphism and the risk of overweight and obesity: A meta-analysis

Autor: Huilan Li, Si-Yun Liu, Jian-Quan Luo, Xiao-Ping Chen, Zan-Lin Zhang, Yan-Jiao Zhang
Rok vydání: 2016
Předmět:
0301 basic medicine
medicine.medical_specialty
BMI
body mass index
Overweight
Article
WHO
World Health Organization
HB
hospital based
03 medical and health sciences
CNKI
Chinese National Knowledge Infrastructure
Internal medicine
G protein β-polypeptide 3
Genetics
Genetic predisposition
medicine
Obesity
MOOSE
guidelines from meta-analysis of observational studies in epidemiology
Polymorphism
GNB3
G protein β-polypeptide 3 gene
Genetics (clinical)
CBM
Chinese Biomedical Medical databases
business.industry
HWE
Hardy–Weinberg equilibrium
Publication bias
Odds ratio
medicine.disease
CIs
confidence intervals
Confidence interval
Meta-analysis
030104 developmental biology
NOS
the Newcastle–Ottawa Quality Assessment Scale
PB
population based
medicine.symptom
PCR–RFLP
polymerase chain reaction–restriction fragment length polymorphism
business
ORs
pooled odds ratios
GNB3
Zdroj: Meta Gene
ISSN: 2214-5400
DOI: 10.1016/j.mgene.2016.03.002
Popis: Background The association between G protein β-polypeptide 3 gene (GNB3) c.825C > T polymorphism (rs5443) and the risk of overweight/obesity has been investigated in many published studies, but the results were conflicting and inconclusive. A meta-analysis was performed to make a more accurate assessment of the relationship. Methods The PubMed, ProQuest Health & Medical Complete, Web of Science, Chinese Biomedical Medical databases (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wan Fang databases were searched to identify eligible literatures. Pooled odds ratios (ORs) with the corresponding 95% confidence intervals (CIs) were used to assess the strength of association between GNB3 c.825C > T polymorphism and overweight/obesity. Results Eleven articles including 15 case–control studies with a total of 10,396 subjects (3171 cases of overweight/obesity and 7225 controls) were enrolled in the meta-analysis. The GNB3 c.825C > T was significantly associated with overweight/obesity under a recessive model (OR = 1.22, 95% CI: 1.04–1.44, P = 0.015). Moreover, the GNB3 825T allele was obviously associated with overweight alone in all inheritable models (P T polymorphism and overweight/obesity risk in males under an allelic model (P = 0.008), a homozygous model (P = 0.014), a recessive model (P = 0.005), and a dominant model (P = 0.049). And the results also showed that GNB3 c.825C > T polymorphism was significantly associated with overweight/obesity in subgroups of mean age less than 30 years, consistent with HWE, and high-quality studies (P = 0.027, P = 0.043, P = 0.040, respectively) under a recessive model, but not in other subgroups. Meta-regression also revealed that P value of HWE, publication year, and the quality scores of studies were the sources of heterogeneity in a recessive model and an allelic model. “Leave one out” sensitivity analyses indicated that the association was more significant after excluding some studies. The funnel plot and Egger's linear regression test and Begg's test revealed no apparent publication bias. Conclusion This meta-analysis suggests that the presence of TT homozygote might be one of the genetic factors susceptible to overweight/obesity and that males or aged under 30 years increase the genetic susceptibility.
Databáze: OpenAIRE
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