The relationship between development of ultraviolet erythema and release of prostaglandins in guinea pig skin
| Autor: | Stewart Sanders Adams, Colin G. Mason, Robert G. Humphries |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Tissue fluid Allergy Erythema Ultraviolet Rays Guinea Pigs Immunology Flurbiprofen Prostaglandin Pharmacology Toxicology Guinea pig chemistry.chemical_compound medicine Animals Potency Pharmacology (medical) skin and connective tissue diseases Skin integumentary system medicine.disease Dermatology Suction blister chemistry Prostaglandins Female medicine.symptom medicine.drug |
| Zdroj: | Agents and Actions. 11:473-476 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf02004708 |
| Popis: | Ultraviolet erythema in the guinea pid has been in use for many years as a model for assessing the anti-inflammatory potency of non-steroidal anti-inflammatory agents, the degree of erythema usually being estimated about 2 h after u.v. exposure. Using a suction blister technique for obtaining tissue fluid from erythemic and normal skin of the guinea pig we have shown that prostaglandin output in ultraviolet-irradiated skin increases rapidly during the first 2 h after irradiation, at which time the erythema reaches near-maximal development. Flurbiprofen, a potent non-steroidal anti-inflammatory agent, almost totally prevents the appearance of prostaglandins in the blister fluid and significantly reduces the degree of erythema in the skin during this early period. However, in flurbiprofen-treated animals, although prostaglandin synthesis is also suppressed at 4 to 5 h after exposure and is still partially suppressed at 17 h, a well developed erythema nevertheless appears by 4 h. This indicates the appearance of one or more non-prostaglandin mediators in the later stages of the reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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