Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors

Autor:	Kamil Paruch, Jose S. Duca, Wolfgang Seghezzi, David A. Parry, Frances Shanahan, Kerry Keertikar, Emma Lees, Carmen S. Alvarez, Doll Ronald J, Timothy J. Guzi, Thierry O. Fischmann, Michael P. Dwyer, Alan Hruza, Nicole Sgambellone, Derek Wiswell, Vincent Madison
Rok vydání:	2007
Předmět:	Pyrimidine Stereochemistry Clinical Biochemistry Pharmaceutical Science Crystallography X-Ray Biochemistry chemistry.chemical_compound Inhibitory Concentration 50 Cyclin-dependent kinase Drug Discovery Molecular Biology Protein Kinase Inhibitors Cyclin-Dependent Kinase Inhibitor Proteins chemistry.chemical_classification Binding Sites biology Bicyclic molecule Molecular Structure Kinase Organic Chemistry Cyclin-dependent kinase 2 Cyclin-Dependent Kinase 2 Combinatorial chemistry Enzyme Template Pyrimidines chemistry Enzyme inhibitor Drug Design biology.protein Molecular Medicine Pyrazoles Protein Binding
Zdroj:	Bioorganicmedicinal chemistry letters. 17(22)
ISSN:	0960-894X
Popis:	A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the in-vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fb0ddeade0a1d1047966807e775062 https://pubmed.ncbi.nlm.nih.gov/17904366 Zobrazit plný text záznamu Full Text from ScienceDirect