Symbiont location, host fitness, and possible coadaptation in a symbiosis between social amoebae and bacteria

Autor: Joan E. Strassmann, Jacob W Miller, Katherine S Geist, Debra A. Brock, Susanne DiSalvo, David C. Queller, Longfei Shu
Rok vydání: 2018
Předmět:
Zdroj: eLife
eLife, Vol 7 (2018)
ISSN: 2050-084X
DOI: 10.7554/elife.42660
Popis: Recent symbioses, particularly facultative ones, are well suited for unravelling the evolutionary give and take between partners. Here we look at variation in natural isolates of the social amoeba Dictyostelium discoideum and their relationships with bacterial symbionts, Burkholderia hayleyella and Burkholderia agricolaris. Only about a third of field-collected amoebae carry a symbiont. We cured and cross-infected amoebae hosts with different symbiont association histories and then compared host responses to each symbiont type. Before curing, field-collected clones did not vary significantly in overall fitness, but infected hosts produced morphologically different multicellular structures. After curing and reinfecting, host fitness declined. However, natural B. hayleyella hosts suffered fewer fitness costs when reinfected with B. hayleyella, indicating that they have evolved mechanisms to tolerate their symbiont. Our work suggests that amoebae hosts have evolved mechanisms to tolerate specific acquired symbionts; exploring host-symbiont relationships that vary within species may provide further insights into disease dynamics.
eLife digest A species can benefit or be hurt by other species. For example, honeybees and flowering plants help each other to flourish, while lions and gazelles behave in ways that decrease each other’s populations. Understanding these relationships is important for controlling pests and diseases. Sometimes it is easiest to study such interactions by looking at simple ones that happen on a small scale. Amoebas are common soil organisms that have the same basic organization as human cells. They are much larger and more complex than the bacteria that also live in the soil. How exactly the amoebas and bacteria interact in the soil is an important question, particularly as some of the bacteria can also live inside amoebas. Does this intimate relationship help or harm the amoeba? Shu, Brock, Geist et al. studied the relationship between a widely studied species of social amoeba and two species of bacteria that can live inside it. Some of the amoebas naturally contained one of the bacteria species, and others were infected with the bacteria in experiments. Throughout the entire life cycle of the amoebas, the bacteria lived inside them. During one part of the life cycle, amoebas form so-called fruiting bodies, which release spores that can develop into new amoebas. Shu et al. found that both types of bacteria alter the structure of the fruiting bodies in ways that reduce how well the spores disperse. One of the bacteria species, called Burkholderia hayleyella, harmed the amoebas a lot. It caused most harm to amoebas that do not naturally host the bacteria. This indicates that the amoebas that do host this species may have evolved to avoid its worst effects. The amoebas have many similarities to the white blood cells that clear bacteria from the human body. Certain bacteria can get inside white blood cells, causing diseases such as tuberculosis. Understanding how bacteria harm amoebas might be useful for understanding such diseases, and developing treatments for them. Though the bacteria Shu et al. studied are not toxic to humans, they are closely related to bacteria that are harmful. It is therefore possible that some bacteria that infect humans first evolve to infect amoebas.
Databáze: OpenAIRE
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