Cumulative pregnancy rates after sequential treatment with modified natural cycle IVF followed by IVF with controlled ovarian stimulation

Autor: Maas Jan Heineman, H. M. Knol, M. J. Pelinck, N. E. A. Vogel, Arnold Simons, Eric Arts, Annemieke Hoek
Přispěvatelé: Reproductive Origins of Adult Health and Disease (ROAHD), Medical Microbiology and Infection Prevention, Obstetrics and Gynaecology
Rok vydání: 2008
Předmět:
Pregnancy Rate
POOR RESPONDERS
medicine.medical_treatment
Twins
Cohort Studies
Gonadotropin-Releasing Hormone
Pregnancy
cumulative pregnancy rate
Birth Weight
BESST
reproductive and urinary physiology
Twin Pregnancy
Obstetrics
Rehabilitation
Obstetrics and Gynecology
ovarian stimulation
female genital diseases and pregnancy complications
Gestation
Female
Follicle Stimulating Hormone
Human
natural cycle
TRIAL
Pregnancy
Multiple
HORMONE ANTAGONIST
SUBFERTILITY
Live birth
Infertility
Female
therapeutics
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
Birth weight
Fertilization in Vitro
Biology
Ovulation Induction
medicine
Humans
COHORT
SINGLE-EMBRYO-TRANSFER
Gynecology
In vitro fertilisation
urogenital system
Infant
Newborn
assisted reproduction
MINIMAL STIMULATION
medicine.disease
Pregnancy rate
Reproductive Medicine
Ovulation induction
IN-VITRO FERTILIZATION
Zdroj: Human Reproduction, 23(8), 1808-1814. Oxford University Press
Human reproduction (Oxford, England), 23(8), 1808-1814. Oxford University Press
ISSN: 1460-2350
0268-1161
DOI: 10.1093/humrep/den155
Popis: BACKGROUND: In modified natural cycle IVF (MNC-IVF), treatment is aimed at using the one follicle that spontaneously develops to dominance, using a GnRH-antagonist together with gonadotrophins in the late follicular phase only. The MNC-IVF is of interest because of its low-risk and patient-friendly profile. The effect of application of MNC-IVF preceding standard IVF with ovarian stimulation on overall results is unknown. METHODS: This single-center cohort study provides follow-up of an earlier study in which nine cycles of MNC-IVF were offered to 268 patients. Ongoing pregnancy rates and live birth rates, as well as time-to-pregnancy after controlled ovarian stimulation-IVF (COS-IVF) following MNC-IVF, were evaluated. RESULTS: Actual observed cumulative ongoing pregnancy rates and live birth rates after sequential treatment with MNC-IVF followed by COS-IVF were 51.5 (95% CI: 45.4-57.6) and 50.0% (95% CI: 43.9-56.1) per patient, of which 8.0 and 6.7% were twins. Median time to ongoing pregnancy was 28.8 weeks. Including treatment-independent pregnancies, cumulative ongoing pregnancy rate was 56.7% (95% CI: 50.7-62.8). CONCLUSIONS: Sequential treatment with MNC-IVF followed by COS-IVF does not appear to compromise overall success rates, while twin pregnancy rate is low. Because of its patient-friendly and low-risk profile, it seems appropriate to perform MNC-IVF preceding COS-IVF.
Databáze: OpenAIRE
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