Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes
| Autor: | Rajan Jain, Matija Snuderl, Danielle Golub, Matt Barnes, Christopher Y. Park, Luis Chiriboga, Michael Kader, Robert H. Newman, Torsten Schöneberg, Dimitris G. Placantonakis, David Fenyö, David Zagzag, Ines Liebscher, Nadim Shohdy, Joshua D. Frenster, Jonathan Serrano, Gabriele Stephan, Niklas Ravn-Boess, Giselle R. Wiggin, James Sun, Devin Bready, Xinyan Huang, Scott Kamen, Douglas MacNeil, John K. Dickson, Sylvia Kurz, Andrew S. Chi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Mutant glioblastoma Biology Malignancy medicine.disease nervous system diseases Gene expression profiling 03 medical and health sciences adhesion 030104 developmental biology 0302 clinical medicine Isocitrate dehydrogenase Glioma glioma Basic and Translational Investigations Cancer research medicine Immunohistochemistry G protein-coupled receptor Receptor neoplasms GPR133 030217 neurology & neurosurgery |
| Zdroj: | Neuro-oncology Advances |
| ISSN: | 2632-2498 |
| Popis: | Background Glioma is a family of primary brain malignancies with limited treatment options and in need of novel therapies. We previously demonstrated that the adhesion G protein-coupled receptor GPR133 (ADGRD1) is necessary for tumor growth in adult glioblastoma, the most advanced malignancy within the glioma family. However, the expression pattern of GPR133 in other types of adult glioma is unknown. Methods We used immunohistochemistry in tumor specimens and non-neoplastic cadaveric brain tissue to profile GPR133 expression in adult gliomas. Results We show that GPR133 expression increases as a function of WHO grade and peaks in glioblastoma, where all tumors ubiquitously express it. Importantly, GPR133 is expressed within the tumor bulk, as well as in the brain-infiltrating tumor margin. Furthermore, GPR133 is expressed in both isocitrate dehydrogenase (IDH) wild-type and mutant gliomas, albeit at higher levels in IDH wild-type tumors. Conclusion The fact that GPR133 is absent from non-neoplastic brain tissue but de novo expressed in glioma suggests that it may be exploited therapeutically. |
| Databáze: | OpenAIRE |
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