Antioxidant effect of cardanol in mixed nanoformulations with pluronic
| Autor: | Carlotta Facchini, Nelsi Zaccheroni, Riccardo Amorati, Francesco Palomba, Susanna Guernelli, Cecilia Prata, Andrea Baschieri, Elisabetta Mezzina |
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| Přispěvatelé: | Nelsi Zaccheroni, Riccardo Amorati , Elisabetta Mezzina , Andrea Baschieri , Francesco Palomba , Cecilia Prata , Carlotta Facchini , Susanna Guernelli |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
medicine.medical_treatment 02 engineering and technology 010402 general chemistry 01 natural sciences Cardanol Pluronic F98 and F108 chemistry.chemical_compound Materials Chemistry Copolymer medicine Mixed micelles Propylene oxide Physical and Theoretical Chemistry Spectroscopy Ethylene oxide Chemistry Poloxamer 021001 nanoscience & nanotechnology Condensed Matter Physics Biocompatible material Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Chemical engineering Pluronic F98 and F108 Cardanol Polyether oxidation Antioxidant Mixed micelles Drug delivery Polyether oxidation 0210 nano-technology |
| Popis: | The use of nontoxic, biocompatible and very stable surfactants in the design and preparation of nanoformulations for drug delivery and food industry applications is a quickly expanding area. In this framework, Pluronics are a well explored class of triblock copolymers presenting hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly(propylene oxide) (PPO) in an A-B-A structure (PEO-PPO-PEO) with different PEO/PPO unit ratio. However, polyethers can undergo oxidation with unpredicted concerns. We describe here the design and characterization, in physiological conditions at 37 °C, of mixed formulations of Pluronic F98 or F108 with 5 or 10% of cardanol (or tert-butyl cardanol), a natural antioxidant that is able to significantly reduce (up to 80%) the detrimental peroxidation. A systematic study will be necessary to fully address the toxicity of these nanosystems but our preliminary MTT assays on fibroblasts are in favour of their benign nature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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