miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes
| Autor: | Carlos Castaño, Enrique Regidor, Anna Novials, Josep Franch-Nadal, Laura Brugnara, M Mata-Cases, Marcelina Párrizas, Carolina Giráldez-García, Xavier Mundet, Xavier Cos, Silvia Canivell |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Oncology medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Prediabetic State 03 medical and health sciences 0302 clinical medicine Endocrinology Microvesicle mir-223 Cell-Derived Microparticles Diabetes mellitus Internal medicine Diagnosis medicine Humans Prediabetes Aged Glycemic Progression business.industry MicroRNA Biomarker Middle Aged medicine.disease Microvesicles MicroRNAs Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Disease Progression Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Journal of Endocrinological Investigation r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-019-01129-z |
| Popis: | Purpose Type 2 diabetes frequently remains undiagnosed for years, whereas early detection of affected individuals would facilitate the implementation of timely and cost-effective therapies, hence decreasing morbidity. With the intention of identifying novel diagnostic biomarkers, we characterized the miRNA profile of microvesicles isolated from retroactive serum samples of normoglycemic individuals and two groups of subjects with prediabetes that in the following 4 years either progressed to overt diabetes or remained stable. Methods We profiled miRNAs in serum microvesicles of a selected group of control and prediabetic individuals participating in the PREDAPS cohort study. Half of the subjects with prediabetes were diagnosed with diabetes during the 4 years of follow-up, while the glycemic status of the other half remained unchanged. Results We identified two miRNAs, miR-10b and miR-223-3p, which target components of the insulin signaling pathway and whose ratio discriminates between these two subgroups of prediabetic individuals at a stage at which other features, including glycemia, are less proficient at separating them. In global, the profile of miRNAs in microvesicles of prediabetic subjects primed to progress to overt diabetes was more similar to that of diabetic patients than the profile of prediabetic subjects who did not progress. Conclusion We have identified a miRNA signature in serum microvesicles that can be used as a new screening biomarker to identify subjects with prediabetes at high risk of developing diabetes, hence allowing the implementation of earlier, and probably more effective, therapeutic interventions. |
| Databáze: | OpenAIRE |
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