Parkinsonism and Neurological Manifestations of Influenza Throughout the 20th and 21st Centuries
| Autor: | Julia Henry, Bayard Miller, Michael S. Okun, Haeman Jang, Richard J. Smeyne |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Pediatrics
medicine.medical_specialty Ataxia Parkinson's disease Databases Factual medicine.disease_cause History 21st Century Article Birds Myelopathy Parkinsonian Disorders Pandemic Influenza Human medicine Animals Humans Pandemics business.industry Parkinsonism virus diseases Outbreak History 19th Century History 20th Century medicine.disease Influenza A virus subtype H5N1 nervous system diseases Neurology History 16th Century Influenza in Birds Immunology Neurology (clinical) Geriatrics and Gerontology medicine.symptom Nervous System Diseases business Encephalitis |
| Popis: | Purpose Given the recent paper by Jang et al. on “A Highly Pathogenic H5N1 Influenza Virus” which reported a novel animal model of parkinsonism, we aimed to perform a complete historical review of the 20th and 21st century literature on parkinsonism and neurological manifestations of influenza. Scope There were at least twelve major flu pandemics reported in the literature in the 20th and 21st century. Neurological manifestations most prevalent during the pandemics included delirium, encephalitis, ocular abnormalities, amyotrophy, myelopathy, radiculopathy, ataxia and seizures. Very little parkinsonism was reported with the exception of the 1917 cases originally described by von Economo. Conclusions To date there have been surprisingly few cases of neurological issues inclusive of parkinsonism associated with influenza pandemics. Given the recent animal model of H5N1 influenza associated parkinsonism, the medical establishment should be prepared to evaluate for the re-emergence of parkinsonism during future outbreaks. |
| Databáze: | OpenAIRE |
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