Effect of vitamin C on fracture healing in elderly Osteogenic Disorder Shionogi rats
| Autor: | Tomás Alcántara-Martos, M. V. Vega, A.D. Delgado-Martínez, L. Munuera-Martinez, M. T. Carrascal |
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| Rok vydání: | 2007 |
| Předmět: |
Vitamin
medicine.medical_specialty Dentistry Ascorbic Acid Bone healing Rats Mutant Strains chemistry.chemical_compound Internal medicine medicine Animals Orthopedics and Sports Medicine Femur Ascorbic Acid Deficiency Fracture Healing Vitamin C business.industry Vitamins Ascorbic acid Biomechanical Phenomena Rats Disease Models Animal Endocrinology chemistry Callus Dietary Supplements Orthopedic surgery Female Surgery Stress Mechanical business Femoral Fractures |
| Zdroj: | The Journal of Bone and Joint Surgery. British volume. :402-407 |
| ISSN: | 2044-5377 0301-620X |
| DOI: | 10.1302/0301-620x.89b3.18007 |
| Popis: | We studied the effect of vitamin C on fracture healing in the elderly. A total of 80 elderly Osteogenic Disorder Shionogi rats were divided into four groups with different rates of vitamin C intake. A closed bilateral fracture was made in the middle third of the femur of each rat. Five weeks after fracture the femora were analysed by mechanical and histological testing. The groups with the lower vitamin C intake demonstrated a lower mechanical resistance of the healing callus and a lower histological grade. The vitamin C levels in blood during healing correlated with the torque resistance of the callus formed (r = 0.525). Therefore, the supplementary vitamin C improved the mechanical resistance of the fracture callus in elderly rats. If these results are similar in humans, vitamin C supplementation should be recommended during fracture healing in the elderly. |
| Databáze: | OpenAIRE |
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