Epidemiology and pathological progression of erythematous lip lesions in captive sun bears (Helarctos malayanus)
| Autor: | Kirsty Officer, Daniela Denk, Nev Broadis, Bethany Jackson, Paul F. Horwood, Vibol Hul, Mathieu Pruvot, Kris Warren, Philippe Dussart, Nhim Thy |
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| Přispěvatelé: | Free the Bears [Phnom Penh, Cambodia], Free the Bears [Australia], Murdoch University, Wildlife Conservation Society (WCS), James Cook University (JCU), International Zoo Veterinary Group [Keighley, UK] (IZVG), Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Ministry of Agriculture, Forestry and Fisheries [Cambodia], Laboratory testing at the Institut Pasteur du Cambodge was supported by funding from the European Union under the INNOVATE programme, through the LACANET project (DCIASIE/2013/315-151). |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Artificial Gene Amplification and Extension Pathology and Laboratory Medicine Polymerase Chain Reaction 0403 veterinary science 0302 clinical medicine MESH: Animals MESH: Phylogeny Phylogeny Mammals education.field_of_study Eukaryota MESH: Carcinoma Squamous Cell MESH: Lip 3. Good health MESH: Erythema Oncology Medical Microbiology 030220 oncology & carcinogenesis Viral Pathogens Lip Neoplasms [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Carcinoma Squamous Cell Disease Progression Medicine MESH: Lip Neoplasms MESH: Disease Progression medicine.medical_specialty Science Bears Surgical and Invasive Medical Procedures Microbiology 03 medical and health sciences Tongue education Molecular Biology Techniques Pathological Microbial Pathogens Molecular Biology MESH: Prevalence Lips Mouth [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health Organisms Biology and Life Sciences Lip Diseases medicine.disease Erythema Face Digestive System MESH: Female Biopsy Risk Factors MESH: Risk Factors Epidemiology Medicine and Health Sciences Prevalence MESH: Gammaherpesvirinae Lip Squamous Cell Carcinoma Multidisciplinary medicine.diagnostic_test 04 agricultural and veterinary sciences medicine.anatomical_structure Vertebrates Viruses MESH: Lip Diseases Female Anatomy Pathogens Cambodia Ursidae Research Article Herpesviruses Histology 040301 veterinary sciences MESH: Ursidae Population Research and Analysis Methods Gammaherpesvirinae medicine Animals Squamous Cell Carcinoma business.industry MESH: Cambodia Carcinoma Cancers and Neoplasms Dermatology Lip MESH: Male stomatognathic diseases Dysplasia Amniotes business DNA viruses Head Zoology |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2020, 15 (12), pp.e0243180. ⟨10.1371/journal.pone.0243180⟩ PLoS ONE, Vol 15, Iss 12, p e0243180 (2020) |
| ISSN: | 1932-6203 |
| Popis: | International audience; This study investigates the occurrence of erythematous lip lesions in a captive sun bear population in Cambodia, including the progression of cheilitis to squamous cell carcinoma, and the presence of Ursid gammaherpesvirus 1. Visual assessment conducted in 2015 and 2016 recorded the prevalence and severity of lesions. Opportunistic sampling for disease testing was conducted on a subset of 39 sun bears, with histopathological examination of lip and tongue biopsies and PCR testing of oral swabs and tissue biopsies collected during health examinations. Lip lesions were similarly prevalent in 2015 (66.0%) and 2016 (68.3%). Degradation of lip lesion severity was seen between 2015 and 2016, and the odds of having lip lesions, having more severe lip lesions, and having lip lesion degradation over time, all increased with age. Cheilitis was found in all lip lesion biopsies, with histological confirmation of squamous cell carcinoma in 64.5% of cases. Single biopsies frequently showed progression from dysplasia to neoplasia. Eighteen of 31 sun bears (58.1%) had at least one sample positive for Ursid gammaherpesvirus 1. The virus was detected in sun bears with and without lip lesions, however due to case selection being strongly biased towards those showing lip lesions it was not possible to test for association between Ursid gammaherpesvirus 1 and lip squamous cell carcinoma. Given gammaherpesviruses can play a role in cancer development under certain conditions in other species, we believe further investigation into Ursid gammaherpesvirus 1 as one of a number of possible co-factors in the progression of lip lesions to squamous cell carcinoma is warranted. This study highlights the progressively neoplastic nature of this lip lesion syndrome in sun bears which has consequences for captive and re-release management. Similarly, the detection of Ursid gammaherpesvirus 1 should be considered in pre-release risk analyses, at least until data is available on the prevalence of the virus in wild sun bears. |
| Databáze: | OpenAIRE |
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