Impact of the histological type on the prognosis of patients with prenatally diagnosed sacrococcygeal teratomas: the results of a nationwide Japanese survey
| Autor: | Mari S. Oba, Tomoo Nakamura, Akihiro Yoneda, Noriaki Usui, Yutaka Kanamori, Shunsuke Nosaka, Haruhiko Sago, Tomoaki Taguchi, Yoshihiro Kitano |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Pediatrics endocrine system diseases Gestational Age Prenatal diagnosis Diagnosis Differential Japan Pregnancy Prenatal Diagnosis Pediatric surgery medicine Humans neoplasms Pelvic Neoplasms Retrospective Studies Gynecology Sacrococcygeal Region business.industry Incidence Incidence (epidemiology) Mortality rate Teratoma Gestational age Retrospective cohort study General Medicine Prognosis medicine.disease female genital diseases and pregnancy complications Survival Rate Fetal Diseases Pediatrics Perinatology and Child Health Female Surgery business Sacrococcygeal teratoma Follow-Up Studies |
| Zdroj: | Pediatric Surgery International. 29:1119-1125 |
| ISSN: | 1437-9813 0179-0358 |
| DOI: | 10.1007/s00383-013-3384-7 |
| Popis: | Purpose To identify the impact of the histological diagnosis on the prognosis of prenatally diagnosed sacrococcygeal teratoma (SCT), we analyzed the data obtained during prenatal surveillance and assessed the postnatal outcomes in a large cohort of fetuses with SCT in Japan. Methods A nationwide retrospective cohort study was conducted among 97 fetuses prenatally diagnosed with SCT between 2000 and 2009. Of these, 84 had a histological diagnosis. In addition, we conducted a second surveillance program of the prognosis of 72 patients who were reported to be alive at the initial surveillance conducted 2 years previously. Results The tumors comprised 51 (61 %) mature teratomas, 33 (39 %) immature teratomas and 0 (0 %) malignant teratomas. Immature teratomas were also associated with a significantly higher mortality rate (immature teratomas: 8/31, mature teratomas: 2/48). Late recurrence was observed in six of 72 cases (8.3 %). Among these six cases, recurrence with a malignant component was observed in four patients. All six patients were successfully treated. Conclusions Mature teratoma was the most common histological type observed in this study. The patients with immature teratomas exhibited an increased risk of mortality. Late recurrence was observed in 8.3 % of the cases. |
| Databáze: | OpenAIRE |
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