Hypertensive intracerebral hemorrhage in young people: previously unnoticed age-related clinical differences
| Autor: | Erwin Chiquete, Fernando Barinagarrementeria, Samuel Romero-Vargas, José Luis Ruiz-Sandoval, Juan J. Padilla-Martínez, Carlos Cantú, Antonio Arauz, Jorge Villarreal-Careaga |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Aging Adolescent Secondary hypertension Intracranial Hemorrhage Hypertensive Essential hypertension Renovascular hypertension medicine Humans Risk factor Stroke Retrospective Studies Advanced and Specialized Nursing Intracerebral hemorrhage business.industry Age Factors Retrospective cohort study medicine.disease Surgery Treatment Outcome Etiology Female Neurology (clinical) Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 37(12) |
| ISSN: | 1524-4628 |
| Popis: | Background and Purpose— Hypertensive intracerebral hemorrhage (ICH) in young people has been the object of only succinct analyses. Therefore, it is unclear whether extrapolation of the information obtained from older patients is also valid for the young. Here we describe young persons with hypertensive ICH and compare them with their older counterparts to determine whether age-related clinical differences exist. Methods— From 1988 to 2004, we studied 35 consecutive young patients with ICH (60% men; mean age, 33 years; range, 15 to 40 years) for whom the etiology of the brain hemorrhage was hypertension. For clinical comparisons, sex-matched persons with hypertensive ICH, aged >40 years, were randomly selected by a factor of 3:1 (n=105). Results— Essential hypertension was present in 26 (74%) young patients and secondary hypertension in 9 (26%), with renovascular hypertension being the most common cause (n=5, 55%). Compared with older patients, the young had higher blood pressures, smaller hemorrhage volumes, lower rates of ventricular extensions (for all, P P =0.05), without cerebellar and lobar locations. Thirty-day mortality was markedly lower in the young than in older persons ( P =0.001), nevertheless at the expense of more incapacitating disabilities. Conclusions— Young people presenting with hypertensive ICH differ in clinical characteristics and have a different prognosis when compared with their older counterparts. These findings suggest underlying age-related differences in disease pathogenesis. |
| Databáze: | OpenAIRE |
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