Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy
| Autor: | Pascual-Goñi, Elba, Martín-Aguilar, Lorena, Lleixà, Cinta, Martinez-Martinez, Laura, Simón-Talero, Manuel J., Diaz-Manera, Jordi., Cortés-Vicente, Elena, Rojas-Garcia, Ricard, Moga, Esther, Juarez, Candido, Illa, Isabel, Querol, Luis, Universitat Autònoma de Barcelona |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Paraproteinemias lcsh:Medicine Context (language use) Article 03 medical and health sciences 0302 clinical medicine Gammopathy medicine Humans lcsh:Science Author Correction Aged Autoantibodies Multidisciplinary biology business.industry lcsh:R Polyradiculoneuropathy Middle Aged medicine.disease IgM Monoclonal Gammopathy Titer Monoclonal gammopathy Myelin-Associated Glycoprotein 030104 developmental biology Immunoglobulin M Polyradiculoneuropathy Chronic Inflammatory Demyelinating nervous system biology.protein Immunohistochemistry lcsh:Q Female Antibody medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Scientific Reports r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Scientific Reports, Vol 9, Iss 1, Pp 1-5 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Antibodies against myelin-associated glycoprotein (MAG) almost invariably appear in the context of an IgM monoclonal gammopathy associated neuropathy. Very few cases of anti-MAG neuropathy lacking IgM-monoclonal gammopathy have been reported. We investigated the presence of anti-MAG antibodies in 69 patients fulfilling diagnostic criteria for CIDP. Anti-MAG antibodies were tested by ELISA and confirmed by immunohistochemistry. We identified four (5.8%) anti-MAG positive patients without detectable IgM-monoclonal gammopathy. In two of them, IgM-monoclonal gammopathy was detected at 3 and 4-year follow-up coinciding with an increase in anti-MAG antibodies titers. In conclusion, anti-MAG antibody testing should be considered in chronic demyelinating neuropathies, even if IgM-monoclonal gammopathy is not detectable. |
| Databáze: | OpenAIRE |
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