Docetaxel (Taxotere) in advanced renal cell cancer. A phase II trial of the EORTC early clinical trials group
| Autor: | Robert Paridaens, P.H.M. de Mulder, Jaap Verweij, U. Bruntsch, B. Heinrich, M. Bayssas, S. B. Kaye, J. Wanders, H. R. Franklin, Jan B. Vermorken, A. van Oosterom |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Paclitaxel Nausea medicine.medical_treatment Phases of clinical research Docetaxel Neutropenia chemistry.chemical_compound Renal cell carcinoma Internal medicine medicine Humans Carcinoma Renal Cell Aged Chemotherapy business.industry Middle Aged medicine.disease Antineoplastic Agents Phytogenic Kidney Neoplasms Surgery chemistry Female Taxoids Premedication medicine.symptom business medicine.drug |
| Zdroj: | European journal of cancer |
| ISSN: | 0959-8049 0014-2964 |
| DOI: | 10.1016/0959-8049(94)90457-x |
| Popis: | Docetaxel (Taxotere), an analogue of paclitaxel, was tested in a phase II study in advanced renal cell carcinoma. Consenting patients with measurable lesions, adequate organ functions and no prior chemotherapy received 100 mg/m2 of docetaxel as a 1-h infusion every 3 weeks. No premedication to avoid hypersensitivity reactions or nausea and emesis was given. 32 eligible patients received 100 treatment cycles. Short-lasting neutropenia was the dose-limiting toxicity. Acute hypersensitivity reactions (HSR), oedema and skin changes were other important side-effects. HSRs regressed spontaneously or were treated with antihistamines with or without corticosteroids. One partial remission was documented. At the dose and schedule used, docetaxel has only low activity against renal cell carcinoma. |
| Databáze: | OpenAIRE |
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