Cardiac adaptation to exercise training in health and disease
| Autor: | Jun Won Heo, Jun Woo Sim, Min Kim, Sam Jun Lee, Dae Yun Seo, Amy Hyein Kim, Se Hwan Park, Hyo-Bum Kwak, Hyun Seok Bang, Jeong Rim Ko, Hyoung Kyu Kim, Jin Han |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell signaling Heart disease Physiology Clinical Biochemistry Cardiomegaly Disease Motor Activity Bioinformatics 03 medical and health sciences 0302 clinical medicine Physiology (medical) Animals Humans Medicine Cardiomegaly Exercise-Induced Pathological business.industry Myocardium Heart medicine.disease Adaptation Physiological Molecular medicine 030104 developmental biology Mitochondrial biogenesis Cardiac hypertrophy Adaptation business 030217 neurology & neurosurgery |
| Zdroj: | Pflügers Archiv - European Journal of Physiology. 472:155-168 |
| ISSN: | 1432-2013 0031-6768 |
| DOI: | 10.1007/s00424-019-02266-3 |
| Popis: | The heart is the primary pump that circulates blood through the entire cardiovascular system, serving many important functions in the body. Exercise training provides favorable anatomical and physiological changes that reduce the risk of heart disease and failure. Compared with pathological cardiac hypertrophy, exercise-induced physiological cardiac hypertrophy leads to an improvement in heart function. Exercise-induced cardiac remodeling is associated with gene regulatory mechanisms and cellular signaling pathways underlying cellular, molecular, and metabolic adaptations. Exercise training also promotes mitochondrial biogenesis and oxidative capacity leading to a decrease in cardiovascular disease. In this review, we summarized the exercise-induced adaptation in cardiac structure and function to understand cellular and molecular signaling pathways and mechanisms in preclinical and clinical trials. |
| Databáze: | OpenAIRE |
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