Validation of a Portable Low-Power Deep Brain Stimulation Device Through Anxiolytic Effects in a Laboratory Rat Model
| Autor: | Ken Walder, Abbas Z. Kouzani, Susannah J. Tye, Pablo Patricio Zarate-Garza, Rajas P. Kale, Michael Berk |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Battery (electricity) Materials science Deep brain stimulation medicine.medical_treatment Deep Brain Stimulation Biomedical Engineering Stimulation Anxiety Sensitivity and Specificity law.invention 03 medical and health sciences 0302 clinical medicine Electric Power Supplies law Internal Medicine medicine Animals Rats Wistar Behavior Animal General Neuroscience Rehabilitation Transistor Reproducibility of Results Signal Processing Computer-Assisted Equipment Design Current source Rats Equipment Failure Analysis 030104 developmental biology Treatment Outcome Brain stimulation Electrode Electronic hardware 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 25(9) |
| ISSN: | 1558-0210 |
| Popis: | Deep brain stimulation (DBS) devices deliver electrical pulses to neural tissue through an electrode. To study the mechanisms and therapeutic benefits of deep brain stimulation, murine preclinical research is necessary. However, conducting naturalistic long-term, uninterrupted animal behavioral experiments can be difficult with bench-top systems. The reduction of size, weight, power consumption, and cost of DBS devices can assist the progress of this research in animal studies. A low power, low weight, miniature DBS device is presented in this paper. This device consists of electronic hardware and software components including a low-power microcontroller, an adjustable current source, an n-channel metal–oxide–semiconductor field-effect transistor, a coin-cell battery, electrode wires and a software program to operate the device. Evaluation of the performance of the device in terms of battery lifetime and device functionality through bench and in vivo tests was conducted. The bench test revealed that this device can deliver continuous stimulation current pulses of strength $200~\mu \text {A}$ , width $90~\mu \text {s}$ , and frequency 130 Hz for over 22 days. The in vivo tests demonstrated that chronic stimulation of the nucleus accumbens (NAc) with this device significantly increased psychomotor activity, together with a dramatic reduction in anxiety-like behavior in the elevated zero-maze test. |
| Databáze: | OpenAIRE |
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