A Lecinoxoid, an oxidized phospholipid small molecule, constrains CNS autoimmune disease

Autor: Eti Ishai, Itzhak Mendel, Oshrat Propheta-Meiran, Anat Shoham, Erez Feige, Gideon Halperin, Eyal Breitbart
Rok vydání: 2010
Předmět:
Central Nervous System
Time Factors
T-Lymphocytes
Freund's Adjuvant
Peptide
Severity of Illness Index
Mice
Oral administration
Immunology and Allergy
Drug Interactions
chemistry.chemical_classification
Mice
Inbred BALB C
biology
Chemistry
Ionomycin
Experimental autoimmune encephalomyelitis
Cell Differentiation
Forkhead Transcription Factors
medicine.anatomical_structure
Neurology
CD4 Antigens
Cytokines
Encephalitis
Female
medicine.symptom
Encephalomyelitis
Autoimmune
Experimental
Phosphorylcholine
Immunology
Central nervous system
Bone Marrow Cells
Enzyme-Linked Immunosorbent Assay
Inflammation
Myelin oligodendrocyte glycoprotein
Polymethacrylic Acids
In vivo
medicine
Animals
Glycoproteins
Autoimmune disease
Ionophores
Dendritic Cells
medicine.disease
Glycerylphosphorylcholine
Peptide Fragments
Mice
Inbred C57BL
Disease Models
Animal
Bromodeoxyuridine
Pertussis Toxin
biology.protein
Myelin-Oligodendrocyte Glycoprotein
Lymph Nodes
Neurology (clinical)
Zdroj: Journal of Neuroimmunology. 226:126-135
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2010.06.011
Popis: Oxidized phospholipids (Ox-PLs) are generated in abundance at sites of inflammation. Recent studies have indicated that Ox-PLs may also exhibit anti-inflammatory activities. In this study, we investigated the beneficial effect of VB-201, a pure synthetic Ox-PL analog that we synthesized, on the development of a central nervous system (CNS) autoimmune inflammatory disease, in vivo. Oral administration of VB-201 ameliorated the severity of experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) peptide MOG35-55, and restrained the encephalogenicity of MOG35-55-specific T-cells. Our data presents a novel prospect for the role of Ox-PL analogs in CNS inflammatory diseases.
Databáze: OpenAIRE
Externí odkaz: