Evaluation the Effects of Eucalyptus Essential Oil and Hypertonic Saline as Scolicidal Agents in Induction of Sclerosing Cholangitis in Rabbits
| Autor: | Pooya Iranpour, Maral Mokhtari, Hajar Khazraei, Shahin Khodaei, Seyed Vahid Hosseini, Maytham Hameed Al-Qanbar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
sclerosing cholangitis medicine.medical_specialty medicine.medical_treatment 030106 microbiology scolicidal agents Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Cholangiography law Internal medicine medicine 030212 general & internal medicine Adverse effect Saline Essential oil Common bile duct medicine.diagnostic_test business.industry Gallbladder General Medicine Hypertonic saline medicine.anatomical_structure Eucalyptus essential oil Duodenum Original Article business |
| Zdroj: | Advanced Biomedical Research |
| ISSN: | 2277-9175 |
| Popis: | Background: There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis (SC) and liver necrosis. The present study aimed to evaluate the adverse effects of Eucalyptus essential oil to induce SC in animal models. Materials and Methods: Eighteen rabbits weighting 2000–3500 g were included in three groups for this study. About 0.3 ml of Eucalyptus essential oil (1%), or 5% hypertonic saline, or normal saline was injected for 5 min in the gallbladder. After 4 months, the liver, common bile duct, and duodenum were resected and immediately sent for cholangiography and pathologic studies. Results: According to pathological studies, inflammation is more common in Eucalyptus and hypertonic saline groups. Due to cholangiographic studies, stricture was slightly higher in the hypertonic saline group than the Eucalyptus group. Conclusion: Thus, 1% Eucalyptus essential oil is at least as safe as 5% hypertonic saline, but for clinical uses, it must be confirmed with further studies. |
| Databáze: | OpenAIRE |
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