Prediction of Cardiac Resynchronization Therapy Response Value of Calibrated Integrated Backscatter Imaging
| Autor: | C. Jan Willem Borleffs, Gaetano Nucifora, Matteo Bertini, Martin J. Schalij, Victoria Delgado, Rutger J. van Bommel, Dennis W. den Uijl, Giuseppe Boriani, Arnold C.T. Ng, Jeroen J. Bax |
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| Přispěvatelé: | Bertini M, Delgado V, den Uijl DW, Nucifora G, Ng AC, van Bommel RJ, Borleffs CJ, Boriani G, Schalij MJ, Bax JJ |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors medicine.medical_treatment Left Myocardial Ischemia Nonischemic heart failure Kidney Aged Calibration Defibrillators Implantable Female Fibrosis Heart Failure Heart Ventricles Humans Logistic Models Middle Aged Odds Ratio Patient Selection Predictive Value of Tests Prospective Studies Risk Assessment Risk Factors Treatment Outcome Ultrasonography Ventricular Dysfunction Left Cardiac Pacing Artificial Electric Countershock Ventricular Remodeling Ventricular Dysfunction Prospective cohort study left ventricular fibrosis cardiac resynchronization therapy calibrated integrated backscatter ischemic heart failure nonischemic heart failure heart-failure patients magnetic-resonance myocardial fibrosis echocardiographic images ischemic cardiomyopathy tissue characterization radial strain scar tissue dyssynchrony trial Cardiac resynchronization therapy Ultrasound Left ventricular fibrosis Parasternal line Predictive value of tests Artificial Cardiology Implantable Cardiology and Cardiovascular Medicine medicine.medical_specialty Renal function NO Internal medicine medicine Radiology Nuclear Medicine and imaging Ventricular remodeling Ischemic heart failure business.industry medicine.disease Calibrated integrated backscatter Heart failure Cardiac Pacing business Defibrillators |
| Zdroj: | Circulation: Cardiovascular Imaging, 3(1), 86-93 |
| Popis: | Background— Left ventricular (LV) fibrosis is important for the response to cardiac resynchronization therapy (CRT). Calibrated integrated backscatter derived by 2D echocardiography quantifies myocardial ultrasound reflectivity, which may provide a surrogate of LV fibrosis. The aim of the study was first, to investigate the relation of myocardial ultrasound reflectivity assessed with calibrated integrated backscatter on CRT response, and second, to explore the “myocardial ultrasound reflectivity–CRT response” relation in patients with ischemic and nonischemic heart failure (HF). Methods and Results— One hundred fifty-nine patients with HF referred for CRT underwent an extensive echocardiographic evaluation at baseline and at 6-month follow-up. LV dyssynchrony was derived from speckle-tracking analysis. Calibrated integrated backscatter was obtained from the parasternal long-axis view. The mean value of calibrated integrated backscatter of the anteroseptal and posterior wall was used to estimate myocardial ultrasound reflectivity. CRT response was defined as reduction ≥15% of LV end-systolic volume. At baseline, LV dyssynchrony was significantly larger in responders as compared with nonresponders (188�96 ms versus 115�68 ms, P P 2 change=40, P Conclusions— Assessment of myocardial ultrasound reflectivity is important in the prediction of CRT response in ischemic and nonischemic patients. |
| Databáze: | OpenAIRE |
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