Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors
| Autor: | Bin Xiao, Qing-Hua Jin, Weiyao Wang, Peng Wan, Fei-Xue Wang, Hua Jin |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Microdialysis Dopamine Spatial Learning Glutamic Acid Morris water navigation task D1-like receptor Hippocampal formation Hippocampus 03 medical and health sciences 0302 clinical medicine Memory medicine Animals Maze Learning Microinjection Memory Disorders Chemistry Receptors Dopamine D1 General Neuroscience Dentate gyrus Glutamate receptor Rats 030104 developmental biology Dentate Gyrus Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain Research Bulletin. 144:101-107 |
| ISSN: | 0361-9230 |
| Popis: | Increasing evidence supports that dopamine (DA) plays an important role in the hippocampal function via activation of D1-like receptors (D1Rs). As the entry structure of the hippocampal formation, the hippocampal dentate gyrus (DG) is critically involved in spatial learning and memory. Despite a number of studies investigated how DA influences CA1 plasticity and learning, there are fewer studies examining the influence of DA signaling to the DG. To investigate the roles of DA and D1Rs of the DG in modulation of spatial learning and memory, the spatial learning and memory abilities of rats were measured by Morris water maze (MWM), and then the concentration of DA in the DG region was determined by in vivo brain microdialysis and HPLC. Next, the effects of local microinjection of SCH23390 (an antagonist of D1Rs) on extracellular levels of excitatory amino acids (EAAs), including glutamate (Glu) and aspartate (Asp), were measured in the DG region during MWM test in freely-moving conscious rats. During the place navigation trial of MWM test, the escape latency was decreased with the increase in training days, and DA concentration in the DG was significantly increased. In SCH23390 group rats, the escape latency was increased in place navigation trial and the percentage of time spent in target quadrant and the number of platform crossings were decreased in spatial probe trial during MWM test, compared with vehicle group. Furthermore, in vehicle group rats, the extracellular levels of Glu and Asp in the DG were significantly increased during place navigation trial of MWM test, and these responses were partly inhibited by microinjection of SCH23390. Our results suggest that DA activation of D1Rs in the hippocampal DG promotes spatial learning and memory, in part by modulating the responses of EAAs during spatial learning. |
| Databáze: | OpenAIRE |
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