Granulomatosis with polyangiitis presenting as facial nerve palsy in a teenager
| Autor: | James C. Wang, Matthew M Smith, Stacey L. Ishman, Brittany A. Leader, Ryan A. Crane, Bernadette L. Koch |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Systemic disease Adolescent Facial Paralysis Antibodies Antineutrophil Cytoplasmic Malaise Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Refractory medicine Humans 030223 otorhinolaryngology Kidney business.industry Granulomatosis with Polyangiitis General Medicine medicine.disease Magnetic Resonance Imaging Decreased appetite Facial Nerve medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Facial nerve palsy Female medicine.symptom Tomography X-Ray Computed business Granulomatosis with polyangiitis Vasculitis Immunosuppressive Agents |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 107:160-163 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2018.02.009 |
| Popis: | Granulomatosis with polyangiitis (GPA, previously known as Wegener's granulomatosis) is an autoimmune systemic small-vessel vasculitis, associated with the presence of anti-neurophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA). It is characterized by necrotizing granulomas, usually affecting the airways and kidneys. GPA should be considered when patients do not improve despite adequate treatment of otologic symptoms, when patients have unspecific symptoms suggesting systemic disease (e.g. fever, malaise), or when other organs are involved (kidney, lungs, etc.). We present an interesting case of a 14-year-old female with eight-weeks of bilateral otalgia, unilateral facial nerve palsy, decreased appetite, and fatigue refractory to steroid, anti-viral, and antibiotic treatment ultimately diagnosed with GPA. |
| Databáze: | OpenAIRE |
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