Rational Exploration of Fold Atlas for Human Solute Carrier Proteins
| Autor: | Tengyu Xie, Ximin Chi, Fangfei Ye, Bangdong Huang, Qiang Zhou, Jing Huang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Solute Carrier Proteins
History Physiological function Polymers and Plastics Chemistry Membrane Transport Proteins Biological Transport SUPERFAMILY Fold (geology) Computational biology Membrane transport Industrial and Manufacturing Engineering Structure and function Solute carrier family Structural Biology Humans Solute transporters Business and International Management Molecular Biology |
| DOI: | 10.1101/2021.08.21.457230 |
| Popis: | Solute carrier (SLC) superfamily is the largest group responsible for transmembrane transport of substances in human cells. It includes more than 400 members which are organized into 65 families according to their physiological function and sequence similarity. Different families of solute transporters can adopt the same or different folds that determine the working mechanism and reflect the evolutionary relationship between SLC members. Analysis of structural data in literatures shows that there are 13 different folds in the solute carrier superfamily covering 40 families and 343 members. To further study their working mechanism, we systematically explored the SLC superfamily to look for more folds. Based on our results, at least three new folds were found for SLC superfamily, and one was experimentally verified in the SLC44 family. Our work has laid a foundation and provided important insights for the systematic and comprehensive study on the structure and function of solute carriers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|