Expectations and limitations of ovarian tissue transplantation
| Autor: | Valdevane Rocha Araújo, A Cordova, K.A. Alves, Johan Smitz, A.P.R. Rodrigues, Nathalie Jiatsa Donfack, José Ricardo de Figueiredo |
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| Přispěvatelé: | Follicle Biology |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Transplantation Heterologous Ovary oncofertility Cryopreservation 03 medical and health sciences 0302 clinical medicine Embryo cryopreservation Internal medicine medicine Animals Humans Fertility preservation Neovascularization Oncofertility 030219 obstetrics & reproductive medicine business.industry Fertility Preservation Cancer Organ Transplantation Cell Biology medicine.disease Premature ovarian failure Transplantation 030104 developmental biology medicine.anatomical_structure Female business transplantation Developmental Biology |
| Zdroj: | Zygote. 25:391-403 |
| ISSN: | 1469-8730 0967-1994 |
| Popis: | SummaryConstant progress in the diagnosis and treatment of cancer disease has increased the number and prognosis of cancer survivors. However, the toxic effects of chemotherapy and radiotherapy on ovarian function have resulted in premature ovarian failure. Patients are, therefore, still expecting methods to be developed to preserve their fertility successfully. Several potential options are available to preserve fertility in patients who face premature ovarian failure, including immature or mature oocyte and embryo cryopreservation. However, for children or prepubertal women needing immediate chemotherapy, cryopreservation of ovarian tissue is the only alternative. The ultimate aim of this strategy is to implant ovarian tissue into the pelvic cavity (orthotopic site) or in a heterotopic site once oncological treatment is completed and the patient is disease free. Transplantation of ovarian tissue with sufficiently large numbers of follicles could potentially restore endocrine function and allow multiple cycles for conception. However, the success of ovarian tissue transplantation still has multiple challenges, such as the low number of follicles in the graft that may affect their longevity as well as the survival of the tissue during ex vivo processing and subsequent transplantation. Therefore, this review aims to summarize the achievements of ovary grafting and the potential techniques that have been developed to improve ovarian graft survival. |
| Databáze: | OpenAIRE |
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