Individualized Therapy with Ranibizumab in Wet Age-Related Macular Degeneration
| Autor: | José Manuel García-Campos, Luis Arias, Jordi Monés, Francisco Cabrera-López, Francisco Gómez-Ulla, Félix Armadá, María I. López-Gálvez, Alfredo García-Layana, E. Cervera, José M. Ruiz-Moreno, Javier Araiz, José García-Arumí, Marta S. Figueroa, Roberto Gallego-Pinazo |
|---|---|
| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry Office visits Gold standard Disease Review Article Macular degeneration medicine.disease Surgery Clinical trial Regimen Ophthalmology lcsh:Ophthalmology lcsh:RE1-994 Oftalmologia Wet age-related macular degeneration medicine Ranibizumab Intensive care medicine business Oftalmopaties Eye diseases medicine.drug |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname Journal of Ophthalmology Journal of Ophthalmology, Vol 2015 (2015) Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| Popis: | Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical trials. A PRN regimen requires monthly visits where the patient is treated in the presence of signs of lesion activity. Therefore, an early detection of reactivation of the disease with immediate retreatment is crucial to prevent visual acuity loss. Several trials suggest that “treat and extend” and other proactive regimens provide a reasonable approach. The rationale of the proactive regimens is to perform treatment anticipating relapses or recurrences and therefore avoid drops in vision while individualizing patient followup. Treat and extend study results in significant direct medical cost savings from fewer treatments and office visits compared to monthly treatment. Current data suggest that, for one year, PRN is less expensive, but treat and extend regimen would likely be less expensive for subsequent years. Once a patient is not a candidate to continue with treatment, he/she should be sent to an outpatient unit with adequate resources to follow nAMD patients in order to reduce the burden of specialized ophthalmologist services. |
| Databáze: | OpenAIRE |
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