Relationship of BK polyoma virus (BKV) in the urine with hemorrhagic cystitis and renal function in recipients of T-cell depleted peripheral blood and cord blood stem cell transplants
| Autor: | Kathleen Choo, Ann A. Jakubowski, Ilya G. Glezerman, Dick Chung, Junting Zheng, Tammy Son, Yeon Joo Lee, Genovefa A. Papanicolaou, Sergio Giralt, Yovanna Kolitsopoulos, Jeff Hester, Isabelle Amigues |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Foscarnet
Adult Male medicine.medical_specialty medicine.medical_treatment viruses T-Lymphocytes Urology Renal function Hematopoietic stem cell transplantation Cord Blood Stem Cell Transplantation medicine.disease_cause Article Cohort Studies chemistry.chemical_compound Young Adult Risk Factors Hemorrhagic cystitis Cystitis Medicine Humans Aged Creatinine Transplantation business.industry virus diseases Hematology Middle Aged medicine.disease 6. Clean water 3. Good health BK virus chemistry Cord blood BK Virus Immunology Female business medicine.drug |
| Popis: | Hematopoietic stem cell transplant (HSCT) recipients are at significant risk for BK virus (BKV) reactivation, hemorrhagic cystitis (HC), and renal dysfunction. We prospectively monitored 98 patients who had received HSCT by serial BKV PCR in the urine through day (D) +100 to analyze the relationship between BK viruria and HC, serum creatinine (Cr), and creatinine clearance (CrCl) through D +180 or death. Patients, median age 52 years (range, 20 to 73), received T cell–depleted (50%) or cord blood allografts (21%). Median pre-HSCT BKV IgG titers were 1:10,240. Incremental increase in BKV IgG titers correlated with developing BK viruria ≥ 107 copies/mL. By D +100, 53 (54%) patients had BK viruria. BKV load in the urine increased at engraftment and persisted throughout D +100. HC developed in 10 patients (10%); 7 of 10 with BK viruria. In competing risk analyses, BK viruria ≥ 107 copies/mL, older age, cytomegalovirus reactivation, and foscarnet use were risk factors for HC. Cr and CrCl at 2, 3, and 6 months after HSCT were similar between patients with and without BK viruria. |
| Databáze: | OpenAIRE |
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