Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan
Autor: | Zoe E. Gillespie, Darrell D. Mousseau, Carla Almendáriz-Palacios, Christopher H. Eskiw |
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Rok vydání: | 2020 |
Předmět: |
mammalian target of rapamycin (mTOR)
general control nonderepressible 2 (GCN2) Population Longevity Health Promotion Review healthspan Bioinformatics Catalysis lcsh:Chemistry Inorganic Chemistry Nutraceutical medicine Animals Humans Physical and Theoretical Chemistry Amino Acids education lcsh:QH301-705.5 Molecular Biology Spectroscopy Cellular Senescence education.field_of_study TOR Serine-Threonine Kinases Organic Chemistry Molecular Mimicry mammalian target of rapamycin (mTOR) Caloric theory General Medicine general control nonderepressible 2 (GCN2) medicine.disease Caloric intake Computer Science Applications Diet Malnutrition lcsh:Biology (General) lcsh:QD1-999 amino acid restriction caloric restriction Energy Intake caloric restriction mimetics lifespan |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 9220, p 9220 (2020) |
ISSN: | 1422-0067 |
Popis: | Caloric restriction (CR), the reduction of caloric intake without inducing malnutrition, is the most reproducible method of extending health and lifespan across numerous organisms, including humans. However, with nearly one-third of the world’s population overweight, it is obvious that caloric restriction approaches are difficult for individuals to achieve. Therefore, identifying compounds that mimic CR is desirable to promote longer, healthier lifespans without the rigors of restricting diet. Many compounds, such as rapamycin (and its derivatives), metformin, or other naturally occurring products in our diets (nutraceuticals), induce CR-like states in laboratory models. An alternative to CR is the removal of specific elements (such as individual amino acids) from the diet. Despite our increasing knowledge of the multitude of CR approaches and CR mimetics, the extent to which these strategies overlap mechanistically remains unclear. Here we provide an update of CR and CR mimetic research, summarizing mechanisms by which these strategies influence genome function required to treat age-related pathologies and identify the molecular fountain of youth. |
Databáze: | OpenAIRE |
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