Performance of the new EULAR/ACR classification criteria for idiopathic inflammatory myopathies (IIM) in a large monocentric IIM cohort
| Autor: | Antonella Notarnicola, Karina Roxana Gheorghe, Ingrid E. Lundberg, Louise Ekholm, Anna Tjärnlund, Matteo Bottai, Simone Barsotti, Lara Dani, Valerie Leclaire, Maryam Dastmalchi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Concordance Sensitivity and Specificity Polymyositis 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Registries 030212 general & internal medicine Aged Retrospective Studies Sweden 030203 arthritis & rheumatology Myositis business.industry Middle Aged Dermatomyositis medicine.disease Clinical trial Anesthesiology and Pain Medicine Cohort Female Inclusion body myositis business Rheumatism |
| Zdroj: | Seminars in Arthritis and Rheumatism. 50:492-497 |
| ISSN: | 0049-0172 |
| DOI: | 10.1016/j.semarthrit.2019.12.001 |
| Popis: | Background In 2017, the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) published new classification criteria for idiopathic inflammatory myopathies (IIM). Objectives To [1] assess the performance of the EULAR/ACR criteria in a monocentric cohort of consecutive patients with IIM, compare them with the Bohan and Peter (BP) criteria, and with the physician's diagnosis; and [2] evaluate the effect of including the presence of interstitial lung disease (ILD) as variable in the criteria. Methods 439 consecutive patients with a diagnosis of IIM followed at the Rheumatology Clinic, Karolinska University Hospital, Sweden were enrolled. The patients were diagnosed as IIM and subclassified by expert physicians. Clinical, laboratory, serological and histopathological data were collected from existing databases (Euromyositis registry and Swedish Rheumatology quality registry) and clinical charts of the patients. The sensitivity of the EULAR/ACR and the BP criteria was calculated. Results The EULAR/ACR criteria had a higher sensitivity (87.7%) compared to the BP criteria (80.4%). The concordance between the two sets of criteria was low (k = 0.253 p 98%) for the major IIM subgroups polymyositis, dermatomyositis, and inclusion body myositis. The sensitivity was variable and was high in inclusion body myositis (98%), dermatomyositis (90%) and lower in polymyositis (73%). When including ILD in the variables of the criteria, six more patients were classified as IIM cases (1.3%). Conclusion The EULAR/ACR criteria for IIM are applicable with high sensitivity and specificity using data available from existing databases and clinical charts and represent a major step forward from the previous criteria for IIM and its subgroups. Their application will improve the quality of clinical trials and research studies with IIM patients. |
| Databáze: | OpenAIRE |
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