Human prostate-specific antigen (APS) is a member of the glandular kallikrein gene family at 19q13
| Autor: | Elizabeth Baker, Grant R. Sutherland, Robert I. Richards, B. A. Evans, J.A. Close, David F. Callen, Geoffrey W. Tregear, V.J. Hyland |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Proteases Subfamily Biology urologic and male genital diseases Serine Antigen Antigens Neoplasm Sequence Homology Nucleic Acid Genetics Humans Gene family Cloning Molecular Molecular Biology Peptide sequence Genetics (clinical) urogenital system Prostate Chromosome Mapping Nucleic Acid Hybridization DNA Kallikrein Prostate-Specific Antigen Molecular biology Prostate-specific antigen Gene Expression Regulation Kallikreins DNA Probes Chromosomes Human Pair 19 circulatory and respiratory physiology |
| Zdroj: | Cytogenetic and Genome Research. 48:205-207 |
| ISSN: | 1424-859X 1424-8581 |
| DOI: | 10.1159/000132629 |
| Popis: | The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein-like family is localized in a single locus on chromosome 7, while other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human × mouse somatic cell hybrid panel to map the APS gene to 19q13, concordant with the renal kallikrein KLK 1 gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse. |
| Databáze: | OpenAIRE |
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