Chemotranscriptome analysis indicates the neurotrophic and neuromodulator effects of a citicoline molecule
| Autor: | O. A. Gromova, V. A. Semenov, I. Yu. Torshin, L. V. Stakhovskaya, I. A. Shchukin |
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| Rok vydání: | 2020 |
| Předmět: |
chemotranscriptome analysis
02 engineering and technology Pharmacology 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Dopamine 0202 electrical engineering electronic engineering information engineering medicine Neurotransmitter metabolism RC346-429 biology Chemistry Dopaminergic citicoline Psychiatry and Mental health Clinical Psychology machine learning Nerve growth factor biology.protein neuroprotection 020201 artificial intelligence & image processing Neurology. Diseases of the nervous system Neurology (clinical) Serotonin 030217 neurology & neurosurgery Acetylcholine medicine.drug Neurotrophin |
| Zdroj: | Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 12, Iss 4, Pp 91-99 (2020) |
| ISSN: | 2310-1342 2074-2711 |
| Popis: | Objective: to investigate the effect of citicoline (CTC) on gene transcription.Material and methods. Chemotranscriptome analysis of the CTC molecule was carried out on an NPC.TAK model, provided that the cells were incubated with CTC for 24 hours.Results and discussion. CTC dose-dependently affected the transcription of 8,838 out of 12,716 annotated human genes, mainly by increasing the transcription of the genes involved: 1) in the neurotransmitter metabolism of serotonin (n=36), dopamine (n=32), GABA (n=14), and acetylcholine (n=27); 2) in showing the effects of neurotrophic factors (n=152), including nerve growth factor (n=11); 3) in maintaining the cardiovascular system (vasodilation and cardiac electrical activity; a total of 76 genes). CTC reduced the transcription of the genes, whose protein activity supported inflammation (n=86) and cell division (n=656). CTC elevated the expression of 60 genes involved in triglyceride processing and decreased the expression of 51 genes whose proteins were involved in cholesterol metabolism. CTC increased the transcription of the genes involved in the body’s response to various drugs, including antiepileptic drugs (n=20), dopaminergic agents (n=19), antipsychotics (n=38), anxiolytics (n=21), sedatives (n=22), antidepressants (n=35), anesthetics (n=23), and antidementia drugs (n=11).Conclusion. Chemotranscriptome analysis indicated the positive effect of CTC on neurotransmission, neuroprotection, lipid profile, and a higher neuronal susceptibility to other neuroactive drugs. |
| Databáze: | OpenAIRE |
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