Evidence that trimethyllysine hydroxylase catalyzes the formation of (2s,3s)-3-hydroxy-n-epsilon-trimethyllysine
| Autor: | Y. Vijayendar Reddy, Jasmin Mecinović, Abbas H. K. Al Temimi, Paul B. White |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oxygenase 010405 organic chemistry Direct evidence Chemistry Organic Chemistry Synthetic Organic Chemistry 01 natural sciences Biochemistry 0104 chemical sciences 03 medical and health sciences 030104 developmental biology Trimethyllysine hydroxylase Carnitine biosynthesis Stereoselectivity Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters, 19, 2, pp. 400-403 Organic Letters, 19, 400-403 |
| ISSN: | 1523-7060 |
| DOI: | 10.1021/acs.orglett.6b03608 |
| Popis: | Trimethyllysine hydroxylase (TMLH) is an Fe(II) and 2-oxoglutarate (2OG) dependent oxygenase involved in the biomedically important carnitine biosynthesis pathway. A combination of synthetic and NMR studies provides direct evidence that human TMLH catalyzes the stereoselective conversion of (2S)-Ne-trimethyllysine to (2S,3S)-3-hydroxy-Ne-trimethyllysine. |
| Databáze: | OpenAIRE |
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