Gene Regulatory Network of ETS Domain Transcription Factors in Different Stages of Glioma
| Autor: | Yigit Koray Babal, Başak Kandemir, Isil Aksan Kurnaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microarray
Gene regulatory network Medicine (miscellaneous) lcsh:Medicine Computational biology Biology ETV1 Article Ets-1 03 medical and health sciences 0302 clinical medicine Elk-1 Glioma glioma medicine Transcription factor Gene 030304 developmental biology 0303 health sciences lcsh:R PEA3 Cancer medicine.disease ETV6 030220 oncology & carcinogenesis biomarker Ets |
| Zdroj: | Journal of Personalized Medicine, Vol 11, Iss 138, p 138 (2021) Journal of Personalized Medicine Volume 11 Issue 2 |
| ISSN: | 2075-4426 |
| Popis: | The ETS domain family of transcription factors is involved in a number of biological processes, and is commonly misregulated in various forms of cancer. Using microarray datasets from patients with different grades of glioma, we have analyzed the expression profiles of various ETS genes, and have identified ETV1, ELK3, ETV4, ELF4, and ETV6 as novel biomarkers for the identification of different glioma grades. We have further analyzed the gene regulatory networks of ETS transcription factors and compared them to previous microarray studies, where Elk-1-VP16 or PEA3-VP16 were overexpressed in neuroblastoma cell lines, and we identify unique and common regulatory networks for these ETS proteins. |
| Databáze: | OpenAIRE |
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