Synchronized On/Off Switching of Four Binding Sites for Water in a Molecular Solomon Link
| Autor: | Fabien B. L. Cougnon, Antonio Frontera, Kenji Caprice, Antonio Bauzá, Marion Pupier |
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| Rok vydání: | 2019 |
| Předmět: |
Molecular switch
010405 organic chemistry Chemistry Polarity (physics) Supramolecular chemistry Cooperative binding Cooperativity General Medicine General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Chemical physics ddc:540 Molecule Binding site Topology (chemistry) |
| Zdroj: | Angewandte Chemie: International Edition, Vol. 58, No 24 (2019) pp. 8053-8057 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201902278 |
| Popis: | A molecular Solomon link adopts different conformations in acetonitrile (1) and in water (2). Contrary to expectations, the main driving force of the transformation is not the change in medium polarity, but the cooperative binding of about four molecules of water, forming a tiny droplet in the central cavity of 2. Mechanistic studies reveal that the four binding sites can simultaneously switch between an inactive state (unable to bind water) and an active state (able to bind water) during the transformation. Spatial and temporal coordination of switching events is commonly observed in biological systems but has been rarely achieved in artificial systems. Here, the concerted activation of the four switchable sites is controlled by the topology of the whole molecule. |
| Databáze: | OpenAIRE |
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