Detection of Circulating Antigens in the Diagnosis of Acute toxoplasmosis
| Autor: | Begona Diez, Pierre Viens, Ramon Cisterna, Acebes Mv, Jose Angel Garcia-Rodriguez |
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| Rok vydání: | 1994 |
| Předmět: |
Antibodies
Protozoan Antigens Protozoan Enzyme-Linked Immunosorbent Assay Biology Rh strain Sensitivity and Specificity Mice Antigen Virology parasitic diseases medicine Animals Strain (chemistry) Inoculation Brain Toxoplasma gondii biology.organism_classification medicine.disease Toxoplasmosis Disease Models Animal Toxoplasmosis Animal Infectious Diseases Immunoglobulin G Acute Disease Immunology Female Parasitology Rabbits Toxoplasma |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 51:506-511 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1994.51.506 |
| Popis: | Using an enzyme-linked immunosorbent assay, we have found circulating antigens of Toxoplasma gondii in three models of murine toxoplasmosis: mice infected with trophozoites of the RH strain (acute toxoplasmosis), the Beverley strain (subacute toxoplasmosis), and the T626 strain (chronic toxoplasmosis). Circulating antigens were detected 48 hr after infection in the mice infected with the RH strain, and all mice had antigenemia by the fourth day. In those infected with the Beverley strain, circulating antigens were detected from the second day after inoculation until the end of the study, with a peak (71% of the infected mice) on day 10. Of those infected with the T626 strain, 40% had antigenemia at 13 days after infection. The detection of circulating antigens in serum is directly related to the presence of toxoplasmosis in the acute phase in the three models studied and, therefore, may prove very useful in the rapid diagnosis of this disease. |
| Databáze: | OpenAIRE |
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