Higher coronary artery calcification score is associated with adverse prognosis in patients with stable angina pectoris
| Autor: | Xin-He Ye, Xin Xu, Xiaoxiao Liu, Renrong Wang, Chunxia Wang, Chengjian Yang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty endocrine system diseases medicine.medical_treatment 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine cardiovascular diseases 030212 general & internal medicine Risk factor Proportional hazards model business.industry Hazard ratio nutritional and metabolic diseases Percutaneous coronary intervention medicine.disease Confidence interval Surgery Conventional PCI cardiovascular system Cardiology population characteristics Original Article business Mace |
| Zdroj: | Journal of Thoracic Disease. 9:582-589 |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd.2017.02.84 |
| Popis: | BACKGROUND Coronary artery calcification (CAC) indicates the presence of atherosclerotic lesions and serves as a marker of prognosis in patients with coronary artery disease (CAD). This study evaluated the value of the CAC score for determining the prognosis of patients with stable angina pectoris (SAP). METHODS A total of 106 consecutive patients with SAP were enrolled in this study from January 2011 to June 2014; from these patients, 640 multi-slice computer tomography (MSCT) samples were used to obtain CAC scores. The CAC scores were calculated according to the standard Agatston calcium scoring algorithm. All subjects were divided into a lower CAC score group (CAC score, ≤300) and a higher CAC score group (CAC score, >300). Major adverse cardiac events (MACE) were followed-up, and the non-event survival time was recorded. The relationships between the CAC score and both clinical characteristics and MACE were then analysed. RESULTS The CAC positively correlated with age and the creatinine (Cr) level. Compared with patients who received lower CAC scores, the rates of percutaneous coronary intervention (PCI), MACE and multi-vessel disease were significantly higher in patients who received higher CAC scores. The Cox regression analysis results showed that the CAC score [pre-standard deviation (SD)] was a risk factor for the no-event survival time [hazard ratio (HR), 3.06; 95% confidence interval (CI), 1.47-6.38; P |
| Databáze: | OpenAIRE |
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