Plasma ghrelin and leptin in patients with inflammatory bowel disease and its association with nutritional status

Autor: Mohammed A Alzoghaibi, Firas Ghomraoui, Saeed Asiri, Waleed Saeed, Maria Saeed, Sami Alotaibi, Majid A Almadi, Nahla Azzam, Meshal Alharthi, Baraa Hajkhder, Abdulrahman M Aljebreen, Othman Alharbi
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
media_common.quotation_subject
Gastroenterology
leptin
Inflammatory bowel disease
Body Mass Index
03 medical and health sciences
0302 clinical medicine
inflammatory bowel disease
Weight loss
Internal medicine
Weight Loss
medicine
Humans
In patient
lcsh:RC799-869
Life Style
media_common
Hepatology
business.industry
Leptin
digestive
oral
and skin physiology
Case-control study
Nutritional status
Appetite
Feeding Behavior
Inflammatory Bowel Diseases
medicine.disease
Ghrelin
nutritional status
030104 developmental biology
Endocrinology
Case-Control Studies
Etiology
Original Article
Female
lcsh:Diseases of the digestive system. Gastroenterology
030211 gastroenterology & hepatology
medicine.symptom
business
Body mass index
management
Hormone
Zdroj: The Saudi Journal of Gastroenterology, Vol 23, Iss 3, Pp 199-205 (2017)
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
ISSN: 1319-3767
DOI: 10.4103/sjg.sjg_575_16
Popis: Background/Aims: Ghrelin and leptin are thought to play a role in the loss of appetite in active inflammatory bowel disease (IBD). This study seeks to probe into the association of these markers with regards to IBD and the nutritional status of these patients. A case-control study was conducted between May 2015 and March 2016 at King Khalid University Hospital (KKUH). Thirty-one patients with IBD (both active and non-active) and forty-one healthy controls (both non-fasting and fasting) were recruited. Patients and Methods: Plasma ghrelin and leptin levels were determined using an enzyme immunoassay (EIA) technique. The nutritional status was determined through the standardized Mini-Nutritional Assessment (MNA) questionnaire. Results: The difference in the plasma ghrelin between active (263.7 pg/mL) and non-active (108 pg/mL) cases was significant (P = 0.02). The difference in mean plasma leptin level between active cases (229.4 pg/mL) vs. non-active cases (359.7 pg/mL) was insignificant (P = 0.4). In fasting (2028.6 pg/mL) and non-fasting controls (438.8 pg/mL), the mean plasma ghrelin values was significantly different (P < 0.01). In contrast, the plasma leptin level difference between fasting (727.3 pg/mL) and non-fasting (577 pg/mL) controls was insignificant (P = 0.14). There is a statistically significant association in mean ghrelin levels between the case group and the control group (P < 0.01). With regards to nutritional status, the mean MNA score of active cases compared to fasting controls was 18.8 ± 5 vs. 20.8 ± 3.8, respectively (P < 0.01) Conclusion: Ghrelin levels were lower in the active IBD cases compared to the inactive ones, signifying an underlying pathology as etiology to this phenomenon. Furthermore, ghrelin levels were significantly lower in both case groups compared to the controls. These findings, along with the disparity in the MNA scores, insinuate a possible link between hormone levels and the loss of appetite from which these patients suffer.
Databáze: OpenAIRE
Externí odkaz: